RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
Pfkfb3
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
qRT-PCR; Immunofluorescence; Western Blot etc.
Target
NA
Pathway
NA
PubMed ID
Title
Anlotinib Inhibits PFKFB3-Driven Glycolysis in Myofibroblasts to Reverse Pulmonary Fibrosis
Year
2021
Function
"These findings suggest that PCBP3 protein upregulation is an early and sustained event during fibroblast activation and that the profibrogenic effects of PCBP3 are mediated by PFKFB3 expression. Taken together, these data suggest that PCBP3 posttranscriptionally increases PFKFB3 expression by promoting its translation during myofibroblast activation."